Increased Insulin Resistance in Obese Children Who Have Both 972 IRS-1 and 1057 IRS-2 Polymorphisms Sophie Le Fur, Catherine Le Stunff, and Pierre Bougnères
http://diabetes.diabetesjournals.org/cgi/content/full/51/suppl_3/S304

The potential effect of the Asp 1057 IRS-2 variant on insulin secretion and insulin sensitivity has been examined in four groups of glucose-tolerant Scandinavian subjects (89).
http://www.fasebj.org/cgi/content/full/15/12/2099

Polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, IRS-1 (Gly 972 Arg) and IRS-2 (Gly 1057 Asp), influence susceptibility to type 2 diabetes.
http://jcem.endojournals.org/cgi/content/full/87/9/4297

GeneCards Home) | GeneCards Guide | User Feedback: WIN AN iPod!!! | Terms of Use | ... IRS-2 3: OTTHUMP00000018696 2
http://www.genecards.org/cgi-bin/carddisp?IRS2

Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes. Author: Sandra Mammarella, et. al. Publication:
https://s100.copyright.com/AppDispatchServlet?publisherName=oup&publication=hmg&title=Interaction+between+the+G1057D+variant+of+IRS-2+and+overweight+in+the+pathogenesis+of+type+2+diabetes&publicationDate=October+1%2C+2000&author=Sandra+Mammarella,+et.+al.&copyright=Copyright+%28c%29+2006+by+the+Oxford+University+Press.&contentID=10.1093/hmg/9.17.2517&volumeNum=9&issueNum=17&startPage=2517&endPage=2521&issn=0964-6906&eissn=1460-2083&orderBeanReset=true

... Macari F, Molinari N, Lefebvre P, Renard E, Gris JC, Cros G, Daures JP, Bringer J, White MF, Grigorescu F 2001 Role of allelic variants Gly 972 Arg of IRS-1 and Gly 1057 Asp of IRS-2 in ...
http://endo.endojournals.org/cgi/content/full/144/6/2683

Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms. Diabetes. 2002; 51:S304?7. doi: 10.2337/diabetes.51.2007.S304. Lei, HH;
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2459151

... compartmentalization and trafficking of insulin receptor substrate (irs)-1 and irs-2 ... pnas, february 19, 2008; 105(7): 2451 - 2456. ...
http://www.jbc.org/cgi/doi/10.1074/jbc.273.19.11548

In this report, we demonstrate that insulin receptor substrate-2 (IRS-2) is phosphorylated ... Virol. 63, 1057-1062 Avanzi, G. C., Lista, P., Giovinazzo, B., Miniero, R., Saglio ...
http://www.jbc.org/cgi/content/full/272/42/26173

First published online on November 23, 2004 Endocrine Reviews, doi:10.1210/er.2004-0004
http://edrv.endojournals.org/cgi/content/full/26/2/251

Endocrinology Vol. 142, No. 3 1057-1064 Copyright © 2001 by The Endocrine Society ... Tyrosine phosphorylation of both IRS-1 and IRS-2 causes the activation of the ...
http://endo.endojournals.org/cgi/content/full/142/3/1057

Invest. 105 (7): 935-943 (2000). doi:10.1172/JCI9017. Copyright © 2000, The ... IRS-1; 5?-GAAGACAGTGGGTACATGCGAATG-3? and 5?-CCTCATGGAGGAAGGCACTGCTG-3? for IRS-2 ...
http://www.jci.org/articles/view/9017

... kinase associates with the insulin receptor substrate (IRS)-related adapter molecules IRS-2 ... Virol. 64: 1057-1062 [Abstract/ Free Full Text]. 55. Shayesteh, L., Y. Lu, W.
http://jvi.asm.org/cgi/content/full/74/7/3037

... operating downstream of insulin receptor ligation have highlighted the importance both of the receptor tyrosine kinase substrates (insulin receptor substrates, IRS-1 and IRS-2) and ...
http://www.jcb.org/cgi/content/full/166/2/213

Upstate Biotechnology, Lake Placid, NY) or rabbit anti-IRS-2 (06-506; Upstate Biotechnology) Abs and 25 µl of protein G-Sepharose beads (Pharmacia Biotech, Uppsala, Sweden), as we ...
http://www.jimmunol.org/cgi/content/full/172/12/7713

Blood, April 1, 2005; 105(7): 2924 - 2932. ... Stat6 and IRS-2 Cooperate in Interleukin 4 (IL-4)-Induced Proliferation and ...
http://www.jimmunol.org/cgi/content/abstract/164/3/1211

... will begin airing Wednesday, Jan. 25, on Reno-based stations KOZZ 105.7-fm and ... Union takes CC Comm expense reports to IRS 2-9-2006 From ...
http://www.nevadalabor.com/unews/cwa/cards.html

Astrophysical Journal, Part 1 (ISSN 0004-637X), vol. 332, Sept. 15, 1988, p. 1049-1057. ... W51, the C I forbidden line emission peaks on the compact IR source and H II region IRS 2 ...
http://adsabs.harvard.edu/abs/1988ApJ...332.1049G

IRS-2-knockout mice exhibit more severe insulin resistance in the liver and peripheral ... J. (2001) Cell 105(7), 821-824 111.Ryves, W. J., and Harwood, A.
http://www.endotext.org/diabetes/diabetes4/diabetesframe4.htm

Vol. 280, Issue 6, E827-E847, June 2001 INVITED REVIEW The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation
http://ajpendo.physiology.org/cgi/content/full/280/6/E827